Introducing a design tournament for Foldit players. Part three of a three-part blog series about the problem of protein design.
A partition function describes the energy landscape of a protein. Part two of a three-part blog series about the problem of protein design.
Discussion of energy landscapes, and how they complicate protein design. Part one of a three-part blog series about the protein design problem.
X-ray diffraction experiments and the first crystal structure of a Foldit design.
Growing a crystal of a Foldit player-designed protein, for crystal x-ray diffraction.
Some promising lab results from recently-tested Foldit designs!
Discussion of protein backbone quality and recent improvements in Foldit designs.
A Foldit player’s question about protein folding pathways.
More details about the recently-introduced Blueprint Panel in Foldit.
Introducing a new tool to Foldit: the Blueprint Panel.
Introducing a new tool in Foldit: the Ramachandran Map.
A discussion of beta-sandwiches and beta-barrels, and some design strategies for sheet-rich proteins.
Foldit players explore protein folds beyond helical bundles.
A walkthrough of the different experiments we use to test designed proteins in the lab
We showcase some of the first Foldit designed proteins to pass computational analysis